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1

The Effect of Mibefradil on Ischemic Episodes With and Without Increase in Heart Rate

Dan Tzivoni, Zvi Gilula, Marc W. Klutstein, Leonardo Reisin, Shulamit Botvin, Isaac Kobrin

Journal:

Cardiovascular Drugs and Therapy

Year:

2000

Language:

english

File:

PDF, 494 KB

english, 2000

2

Antihypertensive effects of mibefradil: A double-blind comparison with diltiazem CD

Barry M. Massie, Steven G Chrysant, Adesh Jain, Matthew Weir, Robert Weiss, Isaac Kobrin

Journal:

Clinical Cardiology

Year:

1997

Language:

english

File:

PDF, 693 KB

english, 1997

3

Rectal involvement in sarcoidosis

Martin Tobi, Isaac Kobrin, Ilana Ariel

Journal:

Diseases of the Colon & Rectum

Year:

1982

Language:

english

File:

PDF, 915 KB

english, 1982

4

Usefulness of an elevated troponin-I in predicting clinical events in patients admitted with acute heart failure and acute coronary syndrome (from the RITZ-4 trial)

Wendy A Gattis, Christopher M O'Connor, Vic Hasselblad, Kirkwood F Adams Jr., Isaac Kobrin, Mihai Gheorghiade

Journal:

The American Journal of Cardiology

Year:

2004

Language:

english

File:

PDF, 81 KB

english, 2004

5

Additional Antianginal and Anti-Ischemic Efficacy of Mibefradil in Patients Pretreated With a Beta Blocker for Chronic Stable Angina Pectoris

Joseph S. Alpert, MD, Isaac Kobrin, MD, Vincent DeQuattro, MD, Richard Friedman, MD, Alexander Shepherd, MD, PhD, Paul E. Fenster, MD, Udho Thadani, MD

Journal:

The American Journal of Cardiology

Year:

1997

Language:

english

File:

PDF, 193 KB

english, 1997

6

Mibefradil in the Treatment of Systemic Hypertension: Comparative Studies With Other Calcium Antagonists

Barry M Massie, MD, Yves Lacourcière, MD, Reuven Viskoper, MD, Arend Woittiez, MD, Isaac Kobrin, MD

Journal:

The American Journal of Cardiology

Year:

1997

Language:

english

File:

PDF, 400 KB

english, 1997

7

Mibefradil in the Treatment of Chronic Stable Angina Pectoris: Comparative Studies With Other Calcium Antagonists

Graham J Davies, MD, Dan Tzivoni, MD, Isaac Kobrin, MD

Journal:

The American Journal of Cardiology

Year:

1997

Language:

english

File:

PDF, 370 KB

english, 1997

8

Safety of Mibefradil, a New Once-a-Day, Selective T-Type Calcium Channel Antagonist

Isaac Kobrin, MD, Vincent Charlon, PhD, Elisabeth Lindberg, MD, Robert Pordy, MD

Journal:

The American Journal of Cardiology

Year:

1997

Language:

english

File:

PDF, 273 KB

english, 1997

9

Antianginal and Anti-ischemic Effects of Mibefradil in the Treatment of Patients with Chronic Stable Angina Pectoris

Joseph S Alpert, MD, Ad L.M Bakx, MD, Shimon Braun, MD, William H Frishman, MD, Adam Schneeweiss, MD, Dan Tzivoni, MD, Isaac Kobrin, MD

Journal:

The American Journal of Cardiology

Year:

1997

Language:

english

File:

PDF, 336 KB

english, 1997

10

Antihypertensive Effects of Mibefradil in the Treatment of Mild-to-Moderate Systemic Hypertension

Suzanne Oparil, MD, Peter Bernink, MD, Michael Bursztyn, MD, Shane Carney, MD, Isaac Kobrin, MD

Journal:

The American Journal of Cardiology

Year:

1997

Language:

english

File:

PDF, 552 KB

english, 1997

11

Long-term renal hemodynamic effects of nadolol in patients with essential hypertension

Edward D. Frohlich, Franz H. Messerli, Gerald R. Deslinski, Isaac Kobrin

Journal:

American Heart Journal

Year:

1984

Language:

english

File:

PDF, 367 KB

english, 1984

12

Effects of the new calcium antagonist mibefradil (Ro 40-5967) on exercise duration in patients with chronic stable angina pectoris: A multicenter, placebo-controlled study

Ad L.M. Bakx, Ernst E. van der Wall, Shimon Braun, Hakan Emanuelsson, Albert V.G. Bruschke, Isaac Kobrin

Journal:

American Heart Journal

Year:

1995

Language:

english

File:

PDF, 994 KB

english, 1995

13

Enalapril improves systemic and renal hemodynamics and allows regression of left ventricular mass in essential hypertension

Francis G. Dunn, Wille Oigman, Hector O. Ventura, Franz H. Messerli, Isaac Kobrin, Edward D. Frohlich

Journal:

The American Journal of Cardiology

Year:

1984

Language:

english

File:

PDF, 542 KB

english, 1984

14

Immediate hemodynamic effects of urapidil in patients with essential hypertension

Isaac Kobrin, Celso Amodeo, Hector O. Ventura, Franz H. Messerli, Edward D. Frohlich

Journal:

The American Journal of Cardiology

Year:

1985

Language:

english

File:

PDF, 430 KB

english, 1985

15

Cardiovascular effects and regional blood flow distribution associated with angiotensin converting enzyme inhibition (captopril) in essential hypertension

Hector O. Ventura, Edward D. Frohlich, Franz H. Messerli, Isaac Kobrin, Merrill B. Kardon

Journal:

The American Journal of Cardiology

Year:

1985

Language:

english

File:

PDF, 497 KB

english, 1985

16

Immediate regional blood flow distribution following angiotensin converting enzyme inhibition in patients with essential hypertension

Hector O. Ventura, Edward D. Frohlich, Franz H. Messerli, Isaac Kobrin, Merrill B. Kardon

Journal:

The American Journal of Medicine

Year:

1984

Language:

english

File:

PDF, 413 KB

english, 1984

17

Early Worsening Heart Failure in Patients Admitted for Acute Heart Failure: Time Course, Hemodynamic Predictors, and Outcome

Guillermo Torre-Amione, Olga Milo-Cotter, Edo Kaluski, Loic Perchenet, Isaac Kobrin, Aline Frey, Michele M. Rund, Beth Davison Weatherley, Gad Cotter

Journal:

Journal of Cardiac Failure

Year:

2009

Language:

english

File:

PDF, 147 KB

english, 2009

18

Long-term antianginal and antiischemic effects of mibefradil, the novel T-type calcium channel blocker: A multicenter, double-blind, placebo-controlled, randomized comparison with sustained-release diltiazem

Graham J. Davies, Isaac Kobrin, Abraham Caspi, Leonardo H. Reisin, Denilson Campos de Albuquerque, Dikran Armagnijan, Otavio Rizzi Coelho, Adam Schneeweiss

Journal:

American Heart Journal

Year:

1997

Language:

english

File:

PDF, 906 KB

english, 1997

19

Mibefradil, a novel calcium antagonist, in elderly patients with hypertension: Favorable hemodynamics and pharmacokinetics

Michael Bursztyn, Honer Kadr, Reijo Tilvis, Benedict Martina, Willie Oigman, Jonas Talberg, Isaac Kobrin

Journal:

American Heart Journal

Year:

1997

Language:

english

File:

PDF, 1.04 MB

english, 1997

20

Adding the new calcium antagonist mibefradil to patients receiving long-term β-blocker therapy results in improved antianginal and antiischemic efficacy

Adam Schneeweiss, Isaac Kobrin, Vincent Charlon, Abraham Caspi, Alon Marmor, Samuel Sclarovsky, Leonardo Reisin, Zvi Zchlesinger

Journal:

American Heart Journal

Year:

1998

Language:

english

File:

PDF, 139 KB

english, 1998

21

Efficacy and safety of cilazapril in elderly patients with essential hypertension: A multicenter study

Isaac Kobrin, Drori Ben-Ishay, Renzo Bompani, Russell Dixon, Russel J. Hoverman, Roy W. Jones, Prisca Kögler, Ramiro Sanchez

Journal:

The American Journal of Medicine

Year:

1989

Language:

english

File:

PDF, 389 KB

english, 1989

22

Evaluating the safety of mibefradil, a selective T-type calcium antagonist, in patients with chronic congestive heart failure

Jan A.F.M. van der Vring, Peter J.L.M. Bernink, Ernst E. van der Wall, Dirk J. van Velhuisen, Shimon Braun, Isaac Kobrin

Journal:

Clinical Therapeutics

Year:

1996

Language:

english

File:

PDF, 595 KB

english, 1996

23

Dose-Response Characteristics of Mibefradil, a Novel Calcium Antagonist, in the Treatment of Essential Hypertension

Suzanne Oparil, Isaac Kobrin, Darrell R Abernethy, Barton S Levine, Max C Reif, Alexander M Shepherd

Journal:

American Journal of Hypertension

Year:

1997

Language:

english

File:

PDF, 356 KB

english, 1997

24

The dual endothelin receptor antagonist tezosentan acutely improves hemodynamic parameters in patients with advanced heart failure

Christoph Schalcher, Gadi Cotter, Leonardo Reisin, Osmund Bertel, Isaac Kobrin, Than-Tam Guyene, Wolfgang Kiowski

Journal:

American Heart Journal

Year:

2001

Language:

english

File:

PDF, 148 KB

english, 2001

25

Tezosentan in patients with acute heart failure and acute coronary syndromes: Design of the Randomized Intravenous Tezosentan Study (RITZ-4)

Christopher M. O'Connor, Wendy A. Gattis, Kirkwood F. Adams Jr, Monica R. Shah, Isaac Kobrin, Aline Frey, Mihai Gheorghiade

Journal:

American Heart Journal

Year:

2002

Language:

english

File:

PDF, 88 KB

english, 2002

26

Multiple dose pharmacokinetics and concentration effect relationship of the orally active renin inhibitor remikiren (Ro 42–5892) in hypertensive patients

Dr CORNELIA WEBER, HERBERT BIRNBÖCK, JOACHIM LEUBE, ISAAC KOBRIN, CORNELIS H. KLEINBLOESEM, PETER VAN BRUMMELEN

Journal:

British Journal of Clinical Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.50 MB

english, 1993

27

Hemodynamic and Cardiac Effects of the Selective T-Type and L-Type Calcium Channel Blocking Agent Mibefradil in Patients With Varying Degrees of Left Ventricular Systolic Dysfunction

MICHEL F ROUSSEAU, WATARU HAYASHIDA, CHRISTIAN van EYLL, OTTO M HESS, CLAUDE R BENEDICT, FRÉDÉRIC CHAPELLE, ISAAC KOBRIN, HUBERT POULEUR

Journal:

Journal of the American College of Cardiology

Year:

1996

Language:

english

File:

PDF, 1.36 MB

english, 1996

28

Results of the Mibefradil Ischemia Suppression Trial (MIST)

Dan Tzivoni, Shimon Braun, Adrianus Schelling, Isaac Kobrin

Journal:

Journal of the American College of Cardiology

Year:

1996

Language:

english

File:

PDF, 264 KB

english, 1996

29

Is High Cholesterol Associate with Improved Survival in Patients with CHF Due to a More Pronounced Effect Statins Therapy in Patients with High- Cholesterol? Results from the Placebo Arm of the ENABLE Study

Olga Milo, Isaac Kobrin, Maurizio Rainisio, Tina Moriconni, Gad Cotter

Journal:

Journal of Cardiac Failure

Year:

2004

Language:

english

File:

PDF, 44 KB

english, 2004

30

Hemodynamic variables (cardiac power) and their changes during 6 hours are the strongest predictors of short-term outcome in acute heart failure

Guillermo Torre-Amione, Olga Milo, Edo Kaluski, Aline Frey, Loic Perchenet, Nir Uriel, Zvi Vered, Isaac Kobrin, Gad Cotter

Journal:

Journal of Cardiac Failure

Year:

2004

Language:

english

File:

PDF, 90 KB

english, 2004

31

An international acute heart failure trial may be more representative of the united states population than united states-based studies: an analysis of the randomized interventions with tezosentan (RITZ-1) trial

John R. Teerlink, Dan Tzivoni, Barry M. Massie, John G.F. Cleland, Isaac Kobrin, Aline Frey, on behalf of the RITZ-1 Investigators

Journal:

Journal of Cardiac Failure

Year:

2004

Language:

english

File:

PDF, 53 KB

english, 2004

32

Echocardiographic ejection fraction in patients with acute heart failure: weak correlations with cardiac contractility and short-term outcome

Nir Uriel, Guillermo Torre-Amione, Olga Milo, Edo Kaluski, Aline Frey, Loic Perchenet, Zvi Vered, Isaac Kobrin, Gad Cotter

Journal:

Journal of Cardiac Failure

Year:

2004

Language:

english

File:

PDF, 53 KB

english, 2004

33

RITZ-5: randomized intravenousTeZosentan (an endothelin-A/B antagonist)for the treatment of pulmonary edema: A prospective, multicenter, double-blind, placebo-controlled study

Edo Kaluski, Isaac Kobrin, Reuven Zimlichman, Alon Marmor, Oscar Krakov, Olga Milo, Aline Frey, Shoshana Kaplan, Rikardo Krakover, Avi Caspi, Zvi Vered, Gad Cotter

Journal:

Journal of the American College of Cardiology

Year:

2003

Language:

english

File:

PDF, 123 KB

english, 2003

34

Tezosentan in patients with acuteheart failure and acute coronary syndromes: Results of the randomized intravenous tezosentan study (ritz-4)

Christopher M O’Connor, Wendy A Gattis, Kirkwood F Adams Jr, Vic Hasselblad, Bleakley Chandler, Aline Frey, Isaac Kobrin, Maurizio Rainisio, Monica R Shah, John Teerlink, Mihai Gheorghiade

Journal:

Journal of the American College of Cardiology

Year:

2003

Language:

english

File:

PDF, 106 KB

english, 2003

35

Hemodynamic and clinical effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients hospitalized for acute decompensated heart failure

Guillermo Torre-Amione, James B Young, Wilson S Colucci, Basil S Lewis, Craig Pratt, Gad Cotter, Karl Stangl, Uri Elkayam, John R Teerlink, Aline Frey, Maurizio Rainisio, Isaac Kobrin

Journal:

Journal of the American College of Cardiology

Year:

2003

Language:

english

File:

PDF, 172 KB

english, 2003

36

1108-116 Cardiac power output is the only independent hemodynamic predictor of outcome in acute heart failure

Gad Cotter, Nir Uriel, Loic Perchenet, Edo Kaluski, Isaac Kobrin, Aline Frey, Olga Milo, Alex Blatt, Shoshana Kaplan, Zvi Vered, Guillermo Torre-Amione

Journal:

Journal of the American College of Cardiology

Year:

2004

Language:

english

File:

PDF, 57 KB

english, 2004

37

1008-191 Statin therapy is associated with a 67 percent reduction in mortality in patients with severe chronic heart failure: Results from the placebo arm of the ENABLE study

Olga Milo, Isaac Kobrin, Aline Frey, Loic Perchenet, Edo Kaluski, Nir Uriel, Alex Blatt, Zvi Vered, Gad Cotter

Journal:

Journal of the American College of Cardiology

Year:

2004

Language:

english

File:

PDF, 120 KB

english, 2004

38

Low dose tezosentan, an intravenous dual endothelin receptor antagonist, decreases type B-natruretic peptide levels in patients with acute decompensated heart failure

Guillermo Torre-Amione, Edo Kaluski, Karl Stangl, Richard Pacher, Christoph Richter, Olga Milo, Loic Perchenet, Isaac Kobrin, Maurizio Rainision, Aline Frey, Eric Neuhart, Zvi Vered, Jasper Dingemanse

Journal:

Journal of Cardiac Failure

Year:

2003

Language:

english

File:

PDF, 75 KB

english, 2003

39

NEW DEVELOPMENTS IN DRUG THERAPY OF HYPERTENSION

Kobrin, Isaac, Charlon, Vincent, Bursztyn, Michael

Journal:

Medical Clinics of North America

Year:

1997

Language:

english

File:

PDF, 754 KB

english, 1997

40

Immediate Hemodynamic Changes Produced by Urapidil in Normotensive and Spontaneously Hypertensive Rats

Kobrin, Isaac, Gallo, Alberto, Kumar, Ajay, Pegram, Barbara L., Frohlich, Edward D.

Journal:

Clinical and Experimental Hypertension

Year:

1984

Language:

english

File:

PDF, 528 KB

english, 1984

41

Prazosin-Induced Bradycardia in Acute Treatment of Hypertension

Journal:

Archives of Internal Medicine

Year:

1983

Language:

english

File:

PDF, 329 KB

english, 1983

42

Renal Involvement Follows Cardiac Enlargement in Essential Hypertension

Journal:

Archives of Internal Medicine

Year:

1986

Language:

english

File:

PDF, 6.43 MB

english, 1986

43

Anti-Anginal and Anti-Ischemic Effects of Mibefradil, a New T-Type Calcium Channel Antagonist

Kobrin, Isaac, Bieska, Gabriele, Charlon, Vincent, Lindberg, Elisabet, Pordy, Robert

Journal:

Year:

1998

Language:

english

File:

PDF, 369 KB

english, 1998

44

The hemodynamic and neurohormonal effects of low doses of tezosentan (an endothelin A/B receptor antagonist) in patients with acute heart failure

Cotter, Gad, Kaluski, Edo, Stangl, Karl, Pacher, Richard, Richter, Christoph, Milo-Cotter, Olga, Perchenet, Loïc, Kobrin, Isaac, Kaplan, Shoshana, Rainisio, Maurizio, Frey, Aline, Neuhart, Eric, Vered

Journal:

European Journal of Heart Failure

Year:

2004

Language:

english

File:

PDF, 408 KB

english, 2004

45

Echocardiographic ejection fraction in patients with acute heart failure: correlations with hemodynamic, clinical, and neurohormonal measures and short-term outcome

Uriel, Nir, Torre-Amione, Guillermo, Milo, Olga, Kaluski, Edo, Perchenet, Loïc, Blatt, Alex, Kobrin, Isaac, Turnovski, Arkadi, Kaplan, Shoshana, Rainisio, Maurizio, Frey, Aline, Vered, Zvi, Cotter, Ga

Journal:

European Journal of Heart Failure

Year:

2005

Language:

english

File:

PDF, 104 KB

english, 2005

46

Clinical and Hemodynamic Effects of Bosentan Dose Optimization in Symptomatic Heart Failure Patients with Severe Systolic Dysfunction, Associated with Secondary Pulmonary Hypertension – A Multi-Center Randomized Study

Kaluski, Edo, Cotter, Gad, Leitman, Marina, Milo-Cotter, Olga, Krakover, Ricardo, Kobrin, Isaac, Moriconi, Tina, Rainisio, Maurizio, Caspi, Avraham, Reizin, Leonardo, Zimlichman, Reuven, Vered, Zvi

Journal:

Year:

2008

Language:

english

File:

PDF, 185 KB

english, 2008

47

Neurohormonal Activation in Acute Heart Failure: Results from VERITAS

Milo-Cotter, Olga, Cotter-Davison, Beth, Lombardi, Carlo, Sun, Hengrui, Bettari, Luca, Bugatti, Silvia, Rund, Michele, Metra, Marco, Kaluski, Edo, Kobrin, Isaac, Frey, Aline, Rainisio, Maurizio, McMur

Journal:

Year:

2011

Language:

english

File:

PDF, 222 KB

english, 2011

48

A Pilot Safety Trial of Prolonged (48 h) Infusion of the Dual Endothelin-Receptor Antagonist Tezosentan in Patients With Advanced Heart Failure

Torre-Amione, Guillermo, Durand, Jean-Bernard, Nagueh, Sheriff, Vooletich, Mary T., Kobrin, Isaac, Pratt, Craig

Journal:

Year:

2001

Language:

english

File:

PDF, 229 KB

english, 2001

49

Comparison of Verapamil and Captopril in Elderly Hypertensive Subjects

Bursztyn, Michael, Ghanem, Jihad, Kobrin, Isaac, Fidel, Joseph, Ben-Ishay, Drori

Journal:

Journal of Cardiovascular Pharmacology

Year:

1993

File:

PDF, 470 KB

1993

50

Right Heart Catheterization: Indications, Technique, Safety, Measurements, and Alternatives

Kaluski, Edo, Shah, Monika, Kobrin, Isaac, Vered, Zvi, Cotter, Gad

Journal:

Year:

2003

Language:

english

File:

PDF, 442 KB

english, 2003

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